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Check Closely (one)pentobarbital will lessen the level or outcome of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the minimize in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, development of a withdrawal syndro